AP+Diabetes+Article+HW

Answer these questions:

1. What are the key players in Diabetes? Why? The key players are the pancreas, liver, muscle and fat These are the key players because insulin is produced in the pancreas that then filters into the liver and goes into the muscles. Diabetes is where there is no or little insulin or to much insulin is produced.

2. What are the unexpected key players in Diabetes? Why? The unexpected key players are the hormones from th skeleton

3. Explain the connection between bones and fat? Leptin is a hormone produced by fat, the fat helps regulated bone metabolism. "Fat regulates bone, bone in essence must regulate fat." said, Dr. Karsenty

4. Explain the connection between bones and the pancreas? The bone produces osteocalcin that tells the tells fat cells and pancreas how to secrete and handle insulin when the glucose moves into the bloodstream into the cells of muscle and the liver.

5. Explain the connection between the brain and diabetes. The brain helps regulate blood sugar and glucose. People with out insulin receptors in the brain can not regulate glucose and would make them have diabetes. Glucose is low when the brain has a sufficient amount of nutrients and hormones causing it to constrain glucose production by the liver. If the brain has an insufficient amount it will cause the liver to make more glucose.

6. Explain the connection between the immune system and diabetes? Fat tissue are extremly large because of the immune cells that are caused by inflammation. This inflammation is related to insulin resistance, which is in all cases of type 2 diabetes. Insulin resistance is the "state of chronic, low-grade inflammation" where the cells are activated.

7. Now summarize the article in a paragraph. There are three key players in diabetes, the pancreas, the liver, muscle and fat. The hormone from the skeleton influences how the body handles sugar. Leptin is a hormone prodiced from fat that helps regulate bone metabolism. The brain helps regulate the blood sugar. Without insulin receptors in the brain the glucose cant regulate correctly. If the brain sense many amounts of hormones it will constrain glucose production by the liver and the blood glucose will be low. If the brain doesnt sense many amounts of hormones it will cause the liver to make more glucose. Inflammation is related to insulin resistance.