AP+Hemophilia

Symptoms:

 * Chronic oozing after injuries
 * tooth extractions or surgery
 * renewed bleeding after initial bleeding has stopped
 * easy or spontaneous bruising
 * chronic bleeding.
 * bleeding include the bowel, the brain and soft tissues.
 * These types of bleeding can lead to throwing up blood or passing blood in the stool, stroke, and sudden severe pain in the joints or limbs.
 * Painful bleeding into the soft tissues of the arms and legs can lead to nerve damage.

Inherited:
When there is an X-linked recessive pattern. An x-linked recessive pattern is when a gene mutation is located on the X chromosome of the two sex chromosomes. In males one altered copy of the gene in each cell of the x-chromosome. In females a mutation must be in both copied of the genes. It can be inherited or could occur randomly. If the mother is a carrier for hemophilia, any daughters she has will be carriers, who can pass the disease to their male children. If both mother and father have this their children will most likely have it. Boys usually have this more than girls.

Treatment:
Replacement therapy: giving or replacing the clotting factor thats too low or missing. You can have this therapy on a regualr basis to prevent bleeding. Clotting factor concentrates can be made made from the human blood but isn't normally. Clotting factors not used from the human blood are called recombinant clotting factors. Making a clotting factor is easy to make and receive the factor.

Complications:
 * Developing antibodies, which are proteins that act against the clotting factors
 * Developing viral infections from human clotting factors
 * Damage to joints, muscles, or other parts of the body resulting from delays in treatment

[|treatment/complications]

Diagnose:
sample of persons blood.
 * Platelet count:**
 * counts the number of blood platelets. This test is normal for people with hemophilia. It helps rule out possible causes of symptoms.
 * Activated partial thromboplastin time (APTT)**
 * measures the length of time that it takes for a blood clot to form
 * amount of time needed for a clot to form is longer than normal for patients with Factor VIII Deficiency (Hemophilia A) and Factor IX Deficiency (Hemophilia B).
 * Factor assay:**
 * most persists test.
 * assay can distinguish between a hemophilia A a hemophilia B

[|Diagnosis]

Causes:
[|Causes 2] [|Causes] Hemophilia A:
 * lack of or mutation of clotting of hemophilia and hemophilia B
 * Hemophiliacs:
 * missing one of these clotting factors which causes them to bleed excessively internally and externally.
 * have different levels of blood clotting factors determined by their genes and causes mild or serious cases
 * Caused by a defect in one of your genes that determine how the body makes blood clotting factors: hemophilia A and B, that are located on the X chromosome
 * X chromosome is the only carrier that has the gene of blood clotting
 * Sine males only have one X chromosome there has to be one abnormal gene on that chromosomse
 * For females to get this gene that have to have an abnormal gene on both of the X chromosome
 * Factor VIII deficiency
 * adding normal plasma to the patient's serum will correct the abnormal APTT test result.(factor assay)
 * 1/3 spontaneous gene mutations.

Hemophilia B
 * factor IX deficiency
 * adding normal serum to the patient's serum will correct the abnormal APTT test result. (factor assay)
 * 1/5 spontaneous gene mutation